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During chronic cold acclimation, KO mice maintained a higher RER than controls, indicating persistent reliance on carbohydrates

Next, considering the duration of drug administration, GLP-1RA has a diminished effect after chronic administration, also known as tachyphylaxis, although the mechanism of tachyphylaxis is currently unclear

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[13] Chloramphenicol has been shown to blunt reticulocyte response to cyanocobalamin, while ethanol, colchicine, and nitrous oxide interfere with cobalamin metabolism or utilization, each warranting clinician awareness when evaluating suboptimal treatment outcomes