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Another group generated isogenic hiPSC lines with engineered mutations in exon 2 and 8 of the DISC1 , leading to loss of long DISC1 isoforms and affecting NPC proliferation, baseline WNT signaling and the expression of NPC fate markers such as FOXG1 and TBR2 [143]

Regardless of the advances, there is no clear evidence of the long-term effect of hydroxyurea in preventing end organ damage (Nevitt et al., 2017

For related reading on how facial rashes are diagnosed and differentiated from one another, the Doctronic.ai blog post on perioral dermatitis covers the clinical presentation and healing process in more depth

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