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Liraglutide can enter specific brain regions associated with appetite regulation, electrophysiological measurements of mouse brain sections showed that GLP-1 directly stimulated promelanocortin (POMC)/cocaine and amphetamine regulated transcript (CART) neurons and indirectly inhibited neurotransmission of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in arcuate nucleus neurons through GABA-dependent signal transduction
Thomas Foltynie of University College London, who led the trial
(PubMed) Horigan G, McNulty H, Ward M, Strain JJ, Purvis J, Scott JM
3 As more employers incorporate digital GLP-1 programs, expect to see insurers incentivize treat-to-target approaches
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