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In rats, supplementation with either phlorotannins, xanthohumol and quercetin (W8-16) [57], kolaviron (P21-35) [59], resveratrol (P51-62) [55] or quercetin (P21-42) [60] dampened the effects of POS-induced anxiety-like behavior as measured in the open field test (OFT) at W12-13 [57], at P35 [59], at P62-65 [55], and at P39-42 [60] and in the LDB at P62-65 [55]

Various studies demonstrated that mushrooms can reduce hyperlipidemia in obese people, such as Lentinula edodes, which has the potential to protect from obesity and possesses anti-hyperlipidemic activity

Diabetes doses go up to 1mg weekly (Ozempic equivalent)

Hypothalamus & Pituitary: GLP-1 enhances GnRH release via kisspeptin/GABA neurons, leading to increased LH and FSH secretion