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Studies on insulinotrophic and anorexigenic effects of GLP-1 only recently have led to the development of a new class of drugs, often referred to as incretin drugs, which act as GLP-1 receptor agonists (GLP-1RAs) and are currently implemented in therapy for T2DM [13]

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Pickart and Thaler isolated it from human serum in 1973 and characterized it as a tripeptide that prolongs survival of normal liver cells and stimulates growth in neoplastic liver tissue 17