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Weight Loss Head-to-Head Retatrutide Phase 2 Results (NEJM 2023) The definitive Phase 2 trial studied retatrutide over 48 weeks in adults with obesity: Primary endpoint (24 weeks) : Up to 17.5% weight loss (12 mg dose) Secondary endpoint (48 weeks) : Up to 24.2% weight loss (12 mg dose) Dose-response : 1 mg (7.2%), 4 mg (12.9%), 8 mg (17.5%), 12 mg (24.2%) 15% responders : 83% achieved clinically significant weight loss at 12 mg Tirzepatide SURMOUNT-1 Results (NEJM 2022) The pivotal Phase 3 trial studied tirzepatide over 72 weeks in adults with obesity: Weight loss by dose : 5 mg (16.0%), 10 mg (21.4%), 15 mg (22.5%) 20% responders : 55% achieved substantial weight loss at 15 mg 25% responders : 36% achieved extreme weight loss at 15 mg Duration advantage : 72-week data vs retatrutide's 48-week data Cross-Trial Comparison Direct head-to-head trials haven't been conducted, but cross-trial analysis shows: Retatrutide advantage: Higher peak weight loss in shorter timeframe suggests superior efficacy

Those conditions increase the risk of serious complications from GLP-1-induced constipation

Those are usually consumer shorthand, not medical categories

By setting clear expectations and staying in communication with your provider, you can feel confident and prepared as you begin