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Phase I Trial Results for SL-401, a Novel Cancer Stem Cell (CSC) Targetign Agent, Demonstrate Clinical Efficacy at Tolerable Doses In Patients with Heavily Pre-Treated AML, Poor Risk Elderly AML, and High Risk MDS

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11d and 11g) Given the differentiation in conformational dynamics of Cagri-bound versus rAmy-bound to CTR or AMYRs and the likely role that the P37 Cagri played in these differences, we also assessed in the assay an analogue of Cagri that contained a P37Y substitution