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There was no difference in age between those with or without brain fog, with age not being associated with BBB dysfunction (Extended Data Fig

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When you lose a significant amount of weight, your body perceives this as a threat and activates powerful compensatory mechanisms: Hunger hormones (particularly ghrelin) increase, intensifying the drive to eat Satiety signals (including leptin) decrease, meaning you feel less full after meals Your resting metabolic rate may reduce, meaning you burn fewer calories at rest The brains reward pathways for food can become more sensitive, increasing cravings Mounjaro effectively overrides these mechanisms whilst it is active

A food sensitivity is an IgG-mediated inflammatory response that typically appears hours to days after the food is eaten