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Researchers also examined major adverse CV events in patient subgroups on the basis of major adverse CV event rates in the placebo group, the presence or absence of CVD, HbA1c level, trial duration, treatment dosing interval, structural homology to human GLP-1 or exendin-4, BMI, age and eGFR

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In contrast, Tesamorelins hexenoyl modification protects it from Dipeptidyl peptidase-4 (DPP-4), extending its half-life to nearly 30 minutes