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GLP is a hormone released from the small intestine in response to food intake
Within the hypothalamus, GLP-1 interacts with pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (it seems to have limited direct access here), a classic site involved in appetite regulation and energy expenditure
in ex vivo distal-lung fibroblasts from smokers and COPD donors, GHK reorganized the actin cytoskeleton, elevated integrin 1, and restored collagen-I contraction and remodeling capacity to levels comparable with TGF- treatment
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