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View on PubMed Contributions by the Brain Renin-Angiotensin System to Memory, Cognition, and Alzheimer's Disease Reviewed the role of brain angiotensin signalling in learning, memory, and neurodegeneration, providing mechanistic context for angiotensin IV analog therapies including Dihexa (J Alzheimers Dis, 2019)
A post hoc subgroup analysis assessing changes in BMI standard-deviation scores between participants with one or more gastrointestinal adverse events and those with none revealed that the effect of liraglutide in reducing BMI standard-deviation scores was independent of gastrointestinal adverse events (P = 0.82) (245)
The post says both forms are contraindicated with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, and that renal impairment, severe hepatic disease or acute pancreatitis calls for provider evaluation either way
Presented for research literature review only Blake RL et al
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