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The body's glucose-sensing mechanisms, which have adapted to chronically elevated blood sugar levels, may initially interpret normal or improved glucose levels as relatively low, potentially triggering hunger signals and cravings for quick-acting carbohydrates
It mimics the activities of the two endogenous hormones, GIP and GLP-1, that exist within the body to regulate blood glucose levels and stimulate appetite
Even when the change is temporary, it can feel alarming
Small-molecule oral GLP-1 RAs, such as orforglipron and danuglipron, are in development or early clinical trials
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