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GLP-1 and glucagon co-agonists Glucagon is secreted from the pancreatic a-cells and the main physiological site of action is the liver to increase hepatic glucose production [60]

(Insulin secretagogues are drugs that help your body release insulin.) Examples of insulin secretagogues include: sulfonylureas, such as glimepiride, glipizide (Glucotrol XL), and glyburide (DiaBeta) meglitinides, such as repaglinide and nateglinide If your blood sugar level drops too low while using insulin or insulin secretagogues with Rybelsus, your doctor may lower your dosage of insulin or insulin secretagogues

While more research is needed, this highlights the importance of moderation

Stress Hormones And Their Link To GLP-1 Plateaus Chronic stress can be a hidden cause of a weight loss plateau