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All current evidence is from animal or in vitro models
Although folic acid is readily absorbed thanks to its single glutamate residue, it is not active as a coenzyme: the enzyme dihydrofolate reductase (DHFR) needs to convert it to tetrahydrofolate for further use [ R , R ]
Oxidative stress occurs when there is an imbalance between free radicalsunstable molecules that can damage cellsand the antioxidants meant to neutralise them
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