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Weeks 12: 2 mg once weekly Weeks 36: 4 mg once weekly Weeks 710: 8 mg once weekly Week 11+: 12 mg once weekly (if tolerated) Fast escalation: Select cases, monitored closely This fast-escalation schedule is used only in specific situations where close supervision is available, such as in specialty clinics or structured clinical trial settings that follow strict safety protocols

For most medications, orange juice, apple juice, or grape juice can be consumed instead of grapefruit juice without any concern for an interaction

By doing so, they can help patients use semaglutide effectively while minimizing the risk of liver-related issues

Patients should be informed about the expected side effect profile before initiating therapy