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Repeated freeze-thaw cycles should be minimized, as they can promote aggregation and reduce biological activity
Oral supplementation almost never produces symptoms because the body absorbs only a small fraction of high-dose oral B12 and excretes the rest
Clinical trials always begin at 2 mg and escalate gradually over 12-16 weeks
The mechanisms already discussed, including enhanced angiogenesis, increased fibroblast activity, collagen synthesis upregulation, and improved cell migration, all contribute to faster resolution of tissue damage
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