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However, protocols and dosing are assessed individually based on health history and goals

doi: 10.1016/j.arr.2005.02.005 179 MahnA.CastilloA

Structural abnormalities of the BBB in CNS disease When multiple CNS diseases (such as Alzheimer's disease, multiple sclerosis, and stroke) occur, the resulting pathological responses (including inflammation, lipid peroxidation, and excitotoxicity) destabilize the BBB, leading to its dysfunction[38, 39]