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"Many times, patients that medically need it maybe those who are obese or have these other weight-related comorbidities don't have easy access to the medication," said Megha Shah, associate professor, physician and study author

Loading phase: Some protocols include a short loading period, while others skip it and still reach similar muscle creatine levels over time

GLP-1RAs deliver high-intensity, pharmacologically sustained signals that reliably induce weight loss, whereas postbiotics provide low-intensity but continuous modulation of gut-derived signaling that shapes metabolic context (Table 1 and conceptually illustrated in Figure 1

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