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It extends beyond a simple aging process, involving irreversible and progressive neurological degeneration that impairs brain function through multiple etiologies
By contrast, serine itself is an allosteric inhibitor of PHGDH, and this allosteric inhibition can spontaneously disappear at low serine levels (Sugimoto and Pizer, 1968)
Reactive oxygen species are produced by electron leak from aerobic respiration by mitochondria
Nutritional optimization (adequate protein, iron, zinc, biotin)
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