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Inconsistent absorption from poor technique can create mini-spikes in drug levels that provoke GI reactions

They stimulate GH through different pathways

Cancer In post-menopausal women, obesity is associated with breast cancer, malignant melanoma, and endometrial cancer [31, 32], whilst both older males and females are at increased risk of hepatobiliary (gallbladder and pancreatic), and genitourinary (renal, bladder, uterine, cervical and prostate) cancers [33]

The improvements in HbA1c and weight loss were also clinically meaningful, the former reflecting evidence from DCCT/EDIC 2,3 and the latter meeting the minimum weight loss (5%) needed for metabolic improvement 41