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Back Jin, T (May 2023) 'Tirzepatide, a new class of incretin-based drug for diabetes' , Obesity Medicine , 39, 1000483
Incretin-based drugs fall into two main categories: DPP-4 inhibitors (like sitagliptin and linagliptin), which block the enzyme that degrades incretin hormones to boost insulin and reduce glucagon levels, and GLP-1 analogues (such as liraglutide and dulaglutide), which mimic natural GLP-1 to enhance insulin release, slow digestion, and promote satiety
It copies part of a larger protein found in human stomach fluid
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