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Key monitoring strategies used in these trials include: Regular laboratory assessments (liver enzymes, lipase and amylase, renal function markers, HbA1c and glucose) Renal function monitoring, particularly if significant gastrointestinal adverse effects occur and dehydration is a concern Cardiovascular monitoring, including resting heart rate and blood pressure GLP-1 and glucagon receptor agonism can increase resting heart rate, which requires careful evaluation in those with pre-existing cardiac conditions Calcitonin measurement and thyroid ultrasound where specified by trial protocol, to monitor for any signal related to thyroid C-cell changes (noting that routine thyroid function tests are not the specific safety assessment for this risk) Body composition assessments using imaging tools, which are research-protocol-specific rather than routine clinical monitoring, to evaluate changes in lean muscle mass versus fat mass Patient-reported outcome measures to capture quality-of-life changes and symptom burden over time Ophthalmic assessments in participants with pre-existing diabetic retinopathy, given the potential for early worsening with rapid glycaemic improvement The glucagon receptor component of retatrutide introduces additional monitoring considerations

While Mounjaro offers significant benefits for blood sugar control, it can also impact the skin in some users

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Brand-Name FDA-Approved Medications Referenced on altRx altRx's source materials also reference brand-name FDA-approved medications at separate listed price points: Mounjaro: Listed at $1,249 per month per altRx's source materials Ozempic: Listed at $1,149 per month per altRx's source materials Wegovy: Listed at $1,579 per month per altRx's source materials Zepbound: Listed at $1,249 per month per altRx's source materials According to altRx's published trademark notice, Wegovy is FDA-approved for weight loss, and Ozempic is FDA-approved for type 2 diabetes treatment but may be prescribed for weight loss at the discretion of a clinician