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Semaglutide is a GLP-1 receptor agonist that reduces appetite, slows gastric emptying, and improves insulin signaling
At 48 weeks, the least-squares mean percentage change in body weight was -8.7% in the 1 mg group, -17.1% in the combined 4 mg group, -22.8% in the combined 8 mg group, and -24.2% in the 12 mg group, compared with -2.1% in the placebo group
Discontinuations due to adverse events were limited, with five participants stopping during the weekly phase and five during the monthly phase across Arms 1 and 3, while no placebo participants discontinued treatment for adverse events
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