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doi: 10.2323/jgam.59.167 374 ShivarathriR.JenullS.StoiberA.ChauhanM.MazumdarR.SinghA.et al

The most commonly reported adverse events in Phase 2 and Phase 3 trials were gastrointestinal in nature, including nausea, diarrhea, vomiting, and constipation

[2] [4] In multi-compartment pharmacokinetics, two operational half-lives are often distinguished: an early distribution () half-life governed by redistribution from the central to peripheral compartments, and a later elimination () half-life governed by metabolic clearance and excretion