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Serotonin syndrome: Combining MDMA with MAO inhibitors, SSRIs, lithium, or other serotonergic agents precipitates serotonin syndrome, a potentially fatal triad of hyperthermia, neuromuscular abnormalities, and altered mental status requiring emergency intervention

Postgraduate Medicine, 133 (3), 310-319

Financial cost (Outcome) Having established that such a trial will need a lengthy duration of follow-up, large sample sizes, the delivery of a complex intervention and therefore a relatively large burden of support

These include: Nausea (the most common complaint, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment or following a dose increase