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They act on receptors in the brain to influence and decrease eating behavior
However, our understanding of the pathophysiology of obesity and of gut hormones has developed precipitously over the last 2030 years
When nausea settles at a stable dose and the slower-moving constipation problem surfaces, that is when fibre becomes the right tool, introduced gradually
The 2025 World Health Organization guideline now recommends GLP-1 therapies (liraglutide, semaglutide, and tirzepatide) as part of long-term obesity treatment in adults, paired with lifestyle interventions (WHO)
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