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HDI, highest density interval
It does not cause gastric irritation, does not interact with semaglutide, and is generally well-tolerated
To characterize the class-level safety profile, K-Dense Web performed a Proportional Reporting Ratio (PRR) disproportionality analysis using the openFDA FAERS API, comparing semaglutide and tirzepatide across six safety signals from 2020 through April 2026
Tirzepatide carries a Boxed Warning regarding thyroid C-cell tumors observed in rodent studies and is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
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