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Although human data are still lacking, the FDA does not recommend using the medication if you have a history of MEN 2 syndrome

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What are the details, background, design and limitations of the study

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Notably, TGF- is considered the master regulator of fibrosis, and its downstream signalling is transduced primarily through the phosphorylation and activation of receptor-associated Smads (R-Smads), Smad2 and Smad3

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