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Nagel, Jonas Binder, Michael Sztucki, Wolfgang Friess, Tim Menzen, Gerhard Winter, Evgenyi Shalaev #Pharmaceuticals #ProteinStability #FreezeDrying #SAXS #Biophysics #OpenScience To view or add a comment, sign in In the phase 3 ACHIEVE clinical trial, Eli Lilly's orforglipron (an oral glucagon-like peptide 1 [GLP-1] receptor agonist) outperformed semaglutide in lowering A1C levels and promoting weight loss over 52 weeks

Presented for research literature review only Koeth RA et al

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Semaglutide, by contrast, comes as a once-weekly injection that bypasses the gastrointestinal absorption pathway entirely, eliminating any competition for intestinal uptake