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In order to minimise the variability in hormone levels and other factors that might affect the pharmacokinetic response, only male subjects were included in the current trials
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GLP-1R-targeted nanomedicines often carry multifunctional payloads, such as GLP-1 analogs, chemotherapeutic agents, and diagnostic compounds, which do not conform to conventional monotherapy trial frameworks [558, 559]
doi: 10.1186/s12967-016-0985-7 39
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