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Additionally, GIP receptor expression in hypothalamic regions and oligodendrocytes suggests central nervous system actions that may synergize with GLP-1 to reduce appetite and food intake while potentially mitigating GLP-1-associated nausea, thereby improving treatment tolerability [36,41,42]
Scaling infrastructure is only part of the equation regulatory readiness is proving just as critical
Activation of several receptors may provide non-additive effects, necessitating comprehensive dose-finding studies to reconcile effectiveness with tolerability
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