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For comparative context: a systematic review of 26 RCTs in 15,491 adults without diabetes found retatrutide 12 mg produced weight loss of up to 22.1% (95% CI 19.3%24.9%) at 48 weeks, exceeding figures for tirzepatide 15 mg (up to 17.8% at 72 weeks) and semaglutide 2.4 mg (up to 13.9% at 68 weeks) in the same literature scan though no head-to-head trial has been conducted, and the comparison is descriptive, not a ranked finding [9]

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