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The expression profile of HSL, within adipocytes, essentially mirrors that of ATGL
Unlike human growth hormone, which can induce hyperglycemia and reduce insulin secretion during extended use, AOD-9604 showed no adverse effect on insulin sensitivity even in long-term animal studies confirmed through euglycemic clamp techniques
AOD-9604's lipolytic activity is suppressed by insulin, so fasted administration is essential
(2000) Heffernan, Jiang, Thorburn, and Ng evaluated the metabolic effects of orally administered AOD-9604 in rodent models and the lipolytic activity of the compound on isolated human adipose tissue ex vivo
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