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In stroke, reduced mitophagy and autophagy may hinder the prompt clearance of damaged mitochondria in the brain, leading to a loss of protection from increased reactive oxygen species (ROS) and reduced mitochondrial ATP supply (Frugier et al., 2015)
Pan-coronavirus vaccine pipeline takes form
and more importantly, these mechanisms remain unclear
Separate mechanistic work confirms exercise itself raises MOTS-c levels in skeletal muscle and blood, linking training load directly to this anti-inflammatory pathway (Gao 2023)
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