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doi:10.1056/NEJMra052166

Therefore, while efforts undoubtedly need to be intensified towards preventing the onset of the disease and making lifestyle modifications (a fundamental aspect of the therapy for every patient with T2DM), it is clear, as indicated by the most recent guidelines [78], that the pharmacological approach should focus on timely treatment that leaves no room for therapeutic inertia and employs medications that are as effective as possible in both metabolic control and the prevention of chronic complications

Evaluation of gastrointestinal distress by the multi-agonists: Pica test To investigate whether multi-agonist therapy is bound to gastrointestinal distress, pica tests were conducted in PWA mice treated with the multi-functional drugs

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