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49 What is more, it has been proposed that citrullination plays a unique role during osteoclast differentiation and ACPA-induced osteoclast activation which might explain important features of the gradual development of RA including why the joints are targeted
Kannt et al
Importantly, weight-matching through calorie restriction or pair-feeding to lean control body weights does not restore leptin signaling in these other BBS models, resulting in persistent hyperleptinemia and increased fat mass (24, 26)
That is the entire mechanism
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