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GLP-1 RAs also have a series of beneficial multifactorial effects beyond glycaemic control that include reduction of body weight and improvement of cardiovascular (CV) outcomes [14]
The combined effect of GIP and GLP results in greater weight loss and also has shown to have greater benefit in lowering blood glucose and lipids
It is specifically contraindicated for individuals with: A personal or family history of medullary thyroid carcinoma (MTC), based on findings of thyroid C-cell tumours in animal studies Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Type 1 diabetes or diabetic ketoacidosis semaglutide is not designed for this purpose Pregnancy, or plans to become pregnant within the next 2 months (semaglutide should be discontinued at least 2 months before attempting conception) Age under 12 years (Wegovy is approved from age 12 only for severe obesity, under specialist supervision) Additional caution is needed for patients with a history of pancreatitis, gallbladder disease, diabetic retinopathy, or significant kidney impairment these patients require closer monitoring throughout treatment
Amyotrophic Lateral Sclerosis/riluzole Study Group II
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