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In the withdrawal trial, continuing preserved loss far better than switching to placebo, which regained about 14% over a year. The metabolic benefit fades in proportion to the weight regained, so a taper plus protein and resistance training beats a hard stop
People who have low B12 levels experience numbness and tingling sensations in their hands and feet
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However, genetic data does not predict exact thermoregulatory response or guarantee specific side effects
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