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What I suggest for all my patients is that they put the cream on the sensitive portion of their inner thighs and take a pin and make a chart as to how soon they do not feel pain from the pinprick and how long it takes before they feel it again
Theres really no long-term human data
A meta-analysis involving more than 70,000 participants with type 2 diabetes (SMART-C) found that the cardiovascular benefits of SGLT-2 inhibitors, including reductions in MACE, cardiovascular death, hospitalisation for HF, and CKD progression, were consistent regardless of whether patients were receiving a GLP-1 receptor agonist at baseline [19]
They looked for new breast cancer cases and discovered that the women using GLP-1s were about 30% less likely to develop the disease
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