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These results help explain how metformin treatment can have a beneficial effect on kidney function and suggests new ways to monitor the effects of metformin on kidney function

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506 A specific form of ASD, known as Rett syndrome (clinically manifested with microcephaly, loss of motor coordination, stereotypic hand wringing, ataxia, seizures, and sleep disturbances) is caused by a loss of function mutation of the methyl-CpG-binding protein 2 or MECP2 gene, expressed in both neurones and neuroglia