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Ion channels, neurotransmitter receptors, and synaptic proteins dominated the landscape of therapeutic targets

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For the apoptosis test, the spheroids were treated with PBS, Ru(II)-OH, NP2, or NP4 for 24 h, respectively (Ru 10 M)

The compound has since been identified in saliva, urine, and various tissue compartments, where endogenous concentrations appear to fluctuate with age and physiological stateobservations that have motivated substantial interest in its biological roles at the cellular and molecular level