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Nonetheless, under certain physiological circumstances (e.g., aging) or in pathologies, coenzyme Q 10 status might be compromised and it is then presumed that supplementation might increase coenzyme Q 10 concentrations in tissues that are deficient (106)
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National Human Genome Research Institute
For example, ROS can facilitate the extrinsic apoptosis pathway through negative regulation of the cellular FLICE-inhibitory protein (Wang et al., 2008) and can induce intrinsic apoptosis pathways by triggering quick release of Cyt-c (Madesh and Hajnoczky, 2001) and regulating the Bcl-2 protein family (Li et al., 2011), and AMPK can be activated by AMPK kinase after H 2 O 2 treatment, which also results in autophagy induction (Galadari et al., 2017)
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