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2024;2:luae156

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In the female offspring, mitochondrial fusion markers on P1 suggest increased mitochondrial regeneration, while in adults increased mitochondrial fission and autophagosome markers were observed, with high levels of MnSOD and OXPHOS complex I suggesting an increase in energy demand and oxidative stress, thereby more mitochondrial turnover (Twig et al., 2008

Notably, long-term effects of empaglifozin on renal and cardiovascular outcomes were assessed with the EMPA REG OUTCOME trial which demonstrated a reduction in the risk of death from cardiovascular disease (HR 0.62, 95% CI, 0.490.77), hospitalization for heart failure (HR 0.65, 95% CI, 0.500.85), and death from any cause (HR 0.68, 95% CI, 0.570.82) [97], as well as slower progression of kidney disease (HR 0.61, 95% CI, 0.53 to 0.70) and lower rates of clinically relevant renal events than placebo (HR 0.54, 95% CI, 0.400.75)