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Orforglipron was FDA approved in April 2026
G_s-protein-coupled pathways are activated when CJC-1295 (No DAC) binds to pituitary GHRH receptors
In the heart, validated studies find the receptor concentrated in the sinoatrial node, which explains the modest increase in heart rate, and in atrial myocytes, where it stimulates the release of atrial natriuretic peptide
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