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Mixed lineage kinase 3 (MLK3) signaling induces ferroptosis-related myocardial fibrosis in mice with advanced chronic heart failure by regulating the NF-B/NLRP3 and JNK/p53 signaling pathways to aggravate oxidative stress [169]
Investigators administered BPC-157 by three routes intraperitoneal injection, oral administration in drinking water, and topical application as a thin cream layer with assessment over a 90-day post-injury period
Front Immunol (2019) 10:2218
These medical-grade formulations bypass the digestive system and are rapidly absorbed through the lungs, helping to reduce inflammation, enhance oxygen exchange, and strengthen immune defense
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