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The gut produced incretins glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) are responsible for an almost ~50% increase of insulin response to orally administered glucose in healthy adults (1), accounting for a large portion of the different insulin response between oral and i.v

4 Discussion In this paper, we present results of lifetime cost-effectiveness analyses on four head-to-head clinical trials investigating the efficacy of oral (PIONEER 2 and PIONEER 3) and subcutaneous semaglutide (SUSTAIN 2 and SUSTAIN 8) compared to empagliflozin, canagliflozin, and sitagliptin

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