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The larger unknown risk is that tens of millions of temporary GLP-1 users develop what is a real issue for many traditionally processed food products a sudden aversion to ultra-processed flavor profiles themselves

Diabetes Care (2012) 35:4857

An adjusted indirect treatment comparison (aITC) was conducted using data from the SURPASS-2 and SUSTAIN FORTE trials

TGR5 activity appears to not have been lost in type 2 diabetic humans whereby the infusion of CCK, or rectal taurocholate, causes GLP-1 and insulin release via the TGR5 axis in colonic L-cells and pancreatic -cells respectively (341, 342)