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It is important to note that curcumin exhibits a biphasic dose-response relationship: lower doses activate protective pathwaysincluding increased total glutathione (GSx) and GST activitywhile higher doses deplete GSH, reduce related metabolites (e.g., taurine, homocysteine), and may induce pro-oxidant effects or cellular toxicity (Scharstuhl et al., 2009)
This multi-system activity maps directly onto what users in the dataset described
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