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Though not everyone experiences addiction in the same way, common signs include: Increasing tolerance Withdrawal symptoms Increased financial instability Lying, cheating, stealing Changes in social, work and family activities and relationships Justifying use or defensive about habits Changes in sleeping patterns Extreme mood swings A person with an addiction disorder usually keeps a stash of the preferred substance on hand and grows distressed when its gone

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Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function