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It can also result in anorectal malformations which can affect the development of the enteric nervous system (27)

however, AChE values remained higher than control levels and were comparable between the two treated groups

Adrenal Suppression (Rare but Serious) Although uncommon with inhaled corticosteroids, prolonged use of high doses of Fluticasone can suppress the adrenal glands

The TRANSCEND-T2D-1 trial results show that the highest dose (12 mg) achieved a mean A1C reduction of 2.0% and an average body weight reduction of 16.8% at 40 weeks